Program & Schedule
Program and Schedule
For the full scientific program, please see below the schedule.
Please note the program and schedule are still being finalised.
Please note the program and schedule are still being finalised.
Detailed Conference Program
15th Sep 2024 (Sunday)
16th Sep 2024 (Monday)
17th Sep 2024 (Tuesday)
18th Sep 2024 (Wednesday)
14:00
Participants Registration
17:30
Opening Ceremony
Chairs: Aljoša Bavec, Marko Goličnik, Stanko Gobec, Jure Stojan
Opening Session
| Time | Lecture |
|---|---|
| 18:00 | Distinguished Plenary Lecture cholinesterases Hermona Soreq, Jerusalem (Israel) A single nucleotide polymorphism in the human AChE gene alters miR-608 levels, anxiety and inflammatory status |
Chairs: Stanko Gobec, Jure Stojan
| Time | Lecture |
|---|---|
| 18:45 | Distinguished Plenary Lecture paraoxonases Carlo Cervellati, Ferrara (Italy) PON1, as a common denominator of neurodegenerative and cardiovascular diseases: proactive player or static biomarker? |
Chairs: Aljoša Bavec, Marko Goličnik
Carlo Cervellati
Hermona Soreq
19:30
Welcome Party
08:30-10:20
Session 1 – Structure and dynamics of cholinesterases, paraoxonases and phosphotriesterases
Chair and keynote lecturer: Joel L. Sussman, Rehovot (Israel)
| Time | Lecture |
|---|---|
| 08:30 | Keynote Lecture: Joel L. Sussman, Rehovot (Israel) An Unusual α/β Hydrolase Fold Enzyme from an Antarctic Bacterium |
| 09:00 | Senior Lecture (20 min): Frank Raushel (USA) Phosphotriesterase Catalyzed Synthesis of Chiral Precursors to Antiviral Prodrugs |
| 09:20 | Senior Lecture (20 min): Doriano Lamba (Italy) Disentangling the Mechanism Underlying the Covalent MethaneSulfonyl Fluoride Acetylcholinesterase Adduct Formation and Evolvement: Structural and Mechanistic Insights into an Aged-like Inactive Complex Susceptible to Reactivation by a Combination of Nucleophiles |
| 09:40 | Senior Lecture (20 min): Anna Linusson Jonsson (Sweden) Acetylcholinesterase Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes |
| 10:00 | Senior Lecture (20 min): Andrey Kovalevsky (USA) Structure and dynamics of hAChE and oxime interactions in structure-based design of novel uncharged bis-oxime reactivators |
Joel L. Sussman
10:20
Coffee Break
10:45-12:35
Session 2 – Interactions of cholinesterases (AChE and BChE) with substrates, inhibitors and reactivators
Chair and keynote lecturer: Zrinka Kovarik, Zagreb (Croatia)
| Time | Lecture |
|---|---|
| 10:45 | Keynote Lecture: Zrinka Kovarik, Zagreb (Croatia) Evaluating cholinesterase’s interactions with inhibitors and potent reactivators towards efficient treatment in organophosphate poisoning |
| 11:15 | Senior Lecture (20 min): Zoran Radić, La Jolla (USA) Towards the fourth generation of effective uncharged bis-oxime reactivators of organophosphate-inhibited human AChE |
| 11:35 | Senior Lecture (20 min): José Dias, Brétigny sur Orge (France) Development and therapeutic potential of uncharged cholinesterase reactivators |
| 11:55 | Senior Lecture (20 min): Jure Stojan, Ljubljana (Slovenia) Direct Determination of the hydrolysis of poor substrates by human plasma |
| 12:15 | Junior Lecture (10 min flash presentation): Xavier Brazzolotto (France) Inhibition of human butyrylcholinesterase by A-series nerve agents, functional and structural characterization |
| 12:25 | Junior Lecture (10 min flash presentation): Gabriele Horn (Germany) Inhibition kinetics of cholinesterases from various species by the organophosphate CBDP in vitro |
Zrinka Kovarik
12:35
Lunch Break
14:00-15:50
Session 3 – Post exposure organo phosphates strategies and toxicology
Chair and keynote lecturer: Ondrej Soukup, Hradec Králové (Czech Republic)
| Time | Lecture |
|---|---|
| 14:00 | Keynote Lecture: Ondrej Soukup, Hradec Králové (Czech Republic) Novichok class of organophosphorus compounds and the efficacy of current countermeasures against A-234 |
| 14:30 | Senior Lecture (20 min): Kamil Musilek (Czech Republic) How to increase bioavailability and follow effect of charged oximes in the central nervous system? |
| 14:50 | Senior Lecture (20 min): Guilhem Calas (France) Novel Strategies for Optimizing the Treatment of Organophosphate Poisoning in a Mouse Model |
| 15:10 | Senior Lecture (20 min): Fredrik Ekström (Sweeden) Choline-O-acetyltransferase as a potential therapeutic target for nerve agent poisoning: Unveiling an ion sensitive regulatory mechanism |
| 15:30 | Junior Lecture (10 min flash presentation): Alexandre Champault (France) Investigation of neuroprotection conferred by a new therapeutic strategy after organophosphorus exposure |
| 15:40 | Junior Lecture (10 min flash presentation): Grégory Dal Bo (France) Blood-brain barrier controlled-opening with ultrasound to improve neuroprotection after nerve agent exposure |
Ondrej Soukup
15:50
Coffee Break
16:15-18:05
Session 4 – Cholinesterase pharmacology, inhibitors and antidotes
Chair and keynote lecturer: Palmer Taylor, San Diego (USA)
| Time | Lecture |
|---|---|
| 16:15 | Keynote Lecture: Palmer Taylor, San Diego (USA) Balancing Central and Peripheral Nervous System Antidotal Actions of Oxime Reactivators to Acetylcholinesterase Inhbition |
| 16:45 | Senior Lecture: Yvonne Rosenberg, Rockville (USA) Development of the post-exposure RS194B oxime against lethal sarin vapour and organophosphate insecticides in macaques |
| 17:05 | Senior Lecture (20 min): Anita Bosak, Zagreb (Croatia) Detection of selective inhibitors of BChE in structurally and functionally different groups of molecules |
| 17:25 | Senior Lecture (20 min): Lukas Gorecki (Czech Republic) Bifunctional compounds serving as versatile cholinesterase reactivators |
| 17:45 | Junior Lecture (10 min flash presentation): Nikolina Maček Hrvat (Croatia) Attenuating organophosphate-induced neuroinflammation in mice by oxime therapy |
| 17:55 | Junior Lecture (10 min flash presentation): Cecilia Springer Engdahl (Sweeden) Design and Evaluation of Acetylcholinesterase Reactivators: A study of reactive oxime- and peripheral site-moieties |
Palmer Taylor
19:30
Dinner
08:30-10:30
Session 5 – Paraoxonase, butyrylcholinesterase and phosphotriesterase role in detoxication, biotechnology and diseases
Chair and keynote lecturer: Eugenio Vilanova-Gisbert, Elche (Spain)
| Time | Lecture |
|---|---|
| 08:30 | Keynote Lecture: Eugenio Vilanova-Gisbert, Elche (Spain) The thin line between substrates or inhibitors: OP-enzymes interactions for biology, toxicity, diagnosis or applications |
| 09:00 | Senior Lecture (20 min): Boštjan Petrič (Slovenia) The Influence of Single Nucleotide Polymorphisms and Substrate Type on Individual Enzyme-Kinetic Rate Constants for Human Plasma PON1 |
| 09:20 | Senior Lecture (20 min): Antonio Monroy Noyola (Mexico) Albumin-copper complex hydrolyses chiral organophosphate compounds as a true A-esterase |
| 09:40 | Senior Lecture (20 min): Jorge Estévez Domènech (Spain) Special behavior of cholinesterase interactions among thiocholine and phenyl carboxyl ester as substrates and inhibitors: Implication for research applications |
| 10:00 | Junior Lecture (10 min flash presentation): Gianmarco Mola (Italy) PON-1 arylesterase activity in older patients with mild cognitive impairment, late onset |
| 10:10 | Junior Lecture (10 min flash presentation): Nagendra Sai Kumar Achanta (Italy) Regulatory mechanism and functional impact of post-translational modifications on human paraoxonase 2 |
| 10:20 | Junior Lecture (10 min flash presentation): Ruihong Zhu (China) Validation and application of two AChE-targeted environmental neurotoxic pollutants detection systems |
Eugenio Vilanova-Gisbert
10:30
Coffee Break
12:35
Lunch Break
14:00
Trip to Bled
19:30
Gala Dinner
08:30-10:20
Session 6 – Translational research of inhibitors of cholinesterases and paraoxonases
Chair and keynote lecturer: Florian Nachon, Brétigny-sur-Orge (France)
| Time | Lecture |
|---|---|
| 08:30 | Keynote Lecture: Florian Nachon, Brétigny-sur-Orge (France) Pharmaceutical development of butyrylcholinesterase |
| 09:00 | Senior Lecture (20 min): Brian Harvey, Potchefstroom (Republic of South Africa) Selective butyrylcholinesterase inhibition induces antidepressant, pro-cognitive, and antianhedonic effects in a genetic animal model of depression: Role of acetylcholine, ghrelin, and dopamine |
| 09:20 | Senior Lecture (20 min): Diego Muñoz-Torrero, Barcelona (Spain) Leveraging templating effects of acetylcholinesterase for the development of new anti-Alzheimer drug candidates with multiple mechanisms |
| 09:40 | Senior Lecture (20 min): Yoko Suzumoto (Italy) A novel identification of anti-hypertensive drug Spironolactone as an inhibitor of Paraoxonase 2 lactonase activity |
| 10:00 | Junior Lecture (10 min flash presentation): Alice Wang (France) Development of pleiotropic prodrugs to treat Alzheimer’s disease: From conception to in vivo evaluation |
| 10:10 | Junior Lecture (10 min flash presentation): Tangui Maurice (France) The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer’s disease |
Florian Nachon
10:20
Coffee Break
10:45-12:35
Session 7 – Multi-target-directed ligands in Alzheimer’s disease primarily targeting cholinesterases
Chair and keynote lecturer: Stanislav Gobec, Ljubljana (Slovenia)
| Time | Lecture |
|---|---|
| 10:45 | Keynote Lecture: Stanislav Gobec, Ljubljana (Slovenia) Multi-target-directed ligands for potential symptomatic and disease-modifying treatment of Alzheimer’s disease |
| 11:15 | Senior Lecture (20 min): Christophe Rochais, Caen (France) Advancing Neocopride: A Preclinical Candidate Multitarget Directed-Ligand (MTDL) for Neurodegenerative Disease Intervention |
| 11:35 | Senior Lecture (20 min): Jose Marco-Contelles, Madrid (Spain) Cholinesterase-based Inhibitors as Multitarget Small Molecules for the therapy of Alzheimer’s Disease |
| 11:55 | Senior Lecture (20 min): Haopeng Sun, Nanjing (China) Discovery of highly selective butyrylcholinesterase inhibitors for cognitive improvement |
| 12:15 | Junior Lecture (10 min flash presentation): Weronika Bagrowska (Poland) Development of dual pharmacophore models of acetylcholinesterase and human soluble epoxide hydrolase based on local co-solvent molecules distribution |
| 12:25 | Junior Lecture (10 min flash presentation): Anže Meden (Slovenia) Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer’s disease |
Stanislav Gobec
12:35
Lunch Break
14:00-16:00
Session 8 – Functions of cholinesterases in different tissues
Chair and keynote lecturer: Karl W.K. Tsim, Hong Kong (China)
| Time | Lecture |
|---|---|
| 14:00 | Keynote Lecture: Karl W.K. Tsim, Hong Kong (China) Acetylcholinesterase Regulates Inflammatory Responses and Pigmentation in Skin Epidermis |
| 14:30 | Senior Lecture (20 min): Anna Hrabovska (Slovakia) Characterizing Cardiac and Vascular Cholinesterases: From Molecular Insights to Therapeutic Prospects |
| 14:50 | Senior Lecture (20 min): Eric Krejci (France) Mice with inactive cholinesterases: new tools to evaluate cholinergic and non-cholinergic functions of AChE |
| 15:10 | Senior Lecture (20 min): Heidi Q Xie (China) New perspectives on the effects of dioxin-like pollutants on acetylcholinesterase |
| 15:30 | Senior Lecture (20 min): Paul G. Layer (Germany) The cholinergic enigma of pigmented and Müller glial cells |
| 15:50 | Junior Lecture (10 min flash presentation): Yingjie Xia (China) Acetylcholinesterase Reliefs Beta-Amyloid Plaque Burden via Enhancing Glial Activation in the Brain of 5×FAD Mouse |
Karl W.K. Tsim
16:30
Closing Lecture
Chair: Jure Stojan
Speaker: Israel Silman, Rehovot (Israel)
Structural Characterization of Orphan and Taxonomically Restricted Proteins
Israel Silman
17:15
17:30
Closing Remarks
Chairs: Aljoša Bavec, Marko Goličnik, Stanislav Gobec, Jure Stojan