Session 1 – Structure and dynamics of cholinesterases, paraoxonases and phosphotriesterases
Chair and keynote lecturer: Joel L. Sussman, Rehovot (Israel)
| Time | Lecture |
|---|---|
| 08:30 | Keynote Lecture: Joel L. Sussman, Rehovot (Israel) An Unusual α/β Hydrolase Fold Enzyme from an Antarctic Bacterium |
| 09:00 | Senior Lecture (20 min): Frank Raushel (USA) Phosphotriesterase Catalyzed Synthesis of Chiral Precursors to Antiviral Prodrugs |
| 09:20 | Senior Lecture (20 min): Doriano Lamba (Italy) Disentangling the Mechanism Underlying the Covalent MethaneSulfonyl Fluoride Acetylcholinesterase Adduct Formation and Evolvement: Structural and Mechanistic Insights into an Aged-like Inactive Complex Susceptible to Reactivation by a Combination of Nucleophiles |
| 09:40 | Senior Lecture (20 min): Anna Linusson Jonsson (Sweden) Acetylcholinesterase Dynamics Determine the Potency and Selectivity of Inhibitors Targeting Disease-Transmitting Mosquitoes |
| 10:00 | Senior Lecture (20 min): Andrey Kovalevsky (USA) Structure and dynamics of hAChE and oxime interactions in structure-based design of novel uncharged bis-oxime reactivators |